STREPTOCOCCUS PNEUMONIAE FAVORS TOLERANCE VIA METABOLIC ADAPTATION OVER RESISTANCE TO CIRCUMVENT FLUOROQUINOLONES

Streptococcus pneumoniae favors tolerance via metabolic adaptation over resistance to circumvent fluoroquinolones

ABSTRACT Streptococcus pneumoniae is a major human pathogen of global health arm cover top concern and the rapid emergence of antibiotic resistance poses a serious public health problem worldwide.Fluoroquinolone resistance in S.pneumoniae is an intriguing case because the prevalence of fluoroquinolone resistance does not correlate with increasing u

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An Adaptive Parallel EI Infilling Strategy Extended by Non-Parametric PMC Sampling Scheme for Efficient Global Optimization

This paper presents a novel adaptive parallel Expected Improvement (EI) infilling strategy for Efficient Global Optimization (EGO) by introducing a two-staged Non-parametric Population Monte Carlo Sampling (NPMS) scheme.The samples are uniformly generated from EI function in the first stage and converge to sub-domains of high EI values thresholded

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